NCOA1 Antibody - middle region (ARP33991_P050)

Catalog No: ARP33991_P050

WB Suggested Anti-NCOA1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: NCI-H226 cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NCOA1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: GLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-NCOA1 (ARP33991_P050) antibody is Catalog # AAP33991 (Previous Catalog # AAPP05066)
• Reference: Lavery,D.N. (2008) Biochemistry 47 (11), 3352-3359

Target Info

• Gene Symbol: NCOA1
• Gene Full Name: Nuclear receptor coactivator 1
• Alias Symbols: SRC1, KAT13A, RIP160, F-SRC-1, bHLHe42, bHLHe74
• NCBI Gene Id: 8648
• Protein Name: Nuclear receptor coactivator 1
• Description of Target: NCOA1 acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. NCOA1 binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion.The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Uniprot ID: Q15788-2
• Protein Accession #: NP_671756
• Nucleotide Accession #: NM_147223
• Protein Size (# AA): 1399
• Molecular Weight: 152kDa
• Protein Interactions: ASCC1; NR1I2; PPARG; AR; VDR; THRB; RXRA; RORB; RORA; RARA; HNF4G; NR6A1; NR5A2; ESRRA; ESR1; PAGR1; Esr2; NR3C1; CXADR; PPARA; AHR; KANK2; NCOA2; TRIM24; NCOA1; ANIB1; PGR; COPS5; UBE2L3; TP53; NCOA6; EP300; UBC; RARB; PPARD; RARG; RBBP6; CREBBP; STAT3;