MUSK Antibody (OAEC04509)

Catalog No: OAEC04509

Size:100 ug/100 ul

Immunohistochemical analysis of paraffin-embedded human lung cancer (A), muscles (B) and breast cancer (C) using MUSK mouse mAb with DAB staining.

Confocal immunofluorescence analysis of HEK293 cells trasfected with extracellular MUSK (aa24-209)-hIgGFc using MUSK mouse mAb (green). Blue. DRAQ5 fluorescent DNA dye.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Ascitic fluid containing 0.03% sodium azide
• Clonality: Monoclonal
• Clone: 10A4
• Isotype: IgG1
• Host: Mouse
• Application: IHC, IF
• Reconstitution and Storage: Store at 4C, for long term storage, store at -20C.
• Immunogen: Purified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.
• Concentration: 1 mg/ml
• Application Info: IHC: 1/200 - 1/1000
  IF: 1/200 - 1/1000
  ELISA: 1/10000
  

Target Info

• Gene Symbol: MUSK
• Gene Full Name: muscle, skeletal, receptor tyrosine kinase
• Alias Symbols: CMS9, FADS, FADS1
• NCBI Gene Id: 4593
• Description of Target: MuSK (for Mus cle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyros ines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.
• Uniprot ID: O15146
• Molecular Weight: 97 kDa