MKI67 Recombinant Protein (OPCD04655)

Catalog No: OPCD04655

MKI67 Recombinant Protein (OPCD04655) using SDS-PAGE

MKI67 Recombinant Protein (OPCD04655) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Cys2386-Val2674
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: >95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Mki67
• Gene Full Name: antigen identified by monoclonal antibody Ki 67
• Alias Symbols: antigen identified by monoclonal antibody Ki-67 homolog;antigen Ki67 homolog;antigen KI-67 homolog;D630048A14Rik;Ki6;Ki-6;Ki67;Ki-67;proliferation marker protein Ki-67.
• NCBI Gene Id: 17345
• Protein Name: Proliferation marker protein Ki-67
• Description of Target: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (By similarity). Does not contribute to the internal structure of mitotic chromosomes (PubMed:26949251). May play a role in chromatin organization (PubMed:26949251). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed.
• Uniprot ID: E9PVX6
• Protein Accession #: NP_001074586.2
• Nucleotide Accession #: NM_001081117.2
• Protein Size (# AA): Cys2386~Val2674
• Molecular Weight: 19/44kDa