Metformin HCl (OOMC00047)

Catalog No: OOMC00047

Product Info

• Product Format: Powder
• Additional Information: CAS: 1115-70-4
  Molecular Formula: C4H11N5 - HCl
  Chemical Name: 1,1-Dimethylbiguanide hydrochloride
  Primary Activity: Antidiabetic agent, Autophagy modulator
  COVID-19 Rationale: Indirect modulator of mTORC1 complex; mTORC1 pathway members interact with SARS-CoV-2 N and Orf8 proteins
• Reconstitution and Storage: Soluble in DMSO (up to 8 mg/ml) or in Water (up to 16 mg/ml). Store at room temperature.
• Purity: > 98%
• Reference: 1) Zhou et al. (2001), Role of AMP-activated protein kinase in mechanism of metformin action; J. Clin. Invest., 108 1167 2) Shaw et al. (2005), The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin; Science, 310 1642 3) Shi et al. (2012), Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy; Cell Death Dis., 3 e275 4) Rego et al. (2017) Anti-tumor effects of metgormin on head and neck carcinoma cell lines: A systemic review; Oncol. Lett., 13 554 5) Lee et al. (2017) PGC1a Activators Mitigate Diabetic Tubulopathy by Improving Mitochondrial Dynamics and Quality Control; J. Diabetes Res., 2017 6483572 6) Zheng et al. (2012) Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin; Diabetes, 61 217 7) Katila et al. (2017) Metformin lowers a-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson’s disease; Neuropharmacology, 125 396

Target Info

• Molecular Weight: 165.63 g/mol