MARK1 Antibody - C-terminal region (ARP74047_P050)

Catalog No: ARP74047_P050

Host: Rabbit
Target Name: MARK1
Sample Type: OVCAR-3 Whole Cell
Antibody Dilution: 1.0ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MARK1
• Purification: Affinity purified
• Peptide Sequence: Synthetic peptide located within the following region: HETGAFAHARRGTSTGIISKITSKFVRRSTSGEPKERDKEEGKDSKPRSL
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-MARK1 (ARP74047_P050) antibody is Catalog # AAP74047
• Reference: N/A

Target Info

• Gene Symbol: MARK1
• Alias Symbols: MARK, Par1c, Par-1c
• NCBI Gene Id: 4139
• Description of Target: MARK1 is a serine/threonine-protein kinase which is involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. It is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also it acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
• Uniprot ID: Q9P0L2-2
• Protein Size (# AA): 645
• Molecular Weight: 70 kDa