LOX1 Antibody (OACD05298)

Catalog No: OACD05298

Western Blot with Bovine Recombinant Oxidized low-density lipoprotein receptor 1

Western Blot with Bovine Recombinant Oxidized low-density lipoprotein receptor 1

Product Info

• Predicted Species Reactivity: Bovine
• Product Format: Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
• Reconstitution and Storage: 2°C to 8°C|-20°C
• Immunogen: Range: Ser57 - Gln270
• Purification: Affinity Purified; Protein A Purified
• Concentration: 0.5 mg/ml
• Preservative: 0.02% NaN3
• Specificity: The antibody is a rabbit polyclonal antibody raised against LOX1. It has been selected for its ability to recognize LOX1 in immunohistochemical staining and western blotting.
• Formulation: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol
• Application Data: Western blotting: 1:50-400
  Immunocytochemistry in formalin fixed cells: 1:50-500
  Immunohistochemistry in formalin fixed frozen section: 1:50-500
  Immunohistochemistry in paraffin section: 1:10-100
  Enzyme-linked Immunosorbent Assay: 1:100-1:5,000
  Optimal working dilutions must be determined by end user.
• Publications:

  Molecular mechanism of statin-mediated LOX-1 inhibition. Cell Cycle. 14, 1583-95 (2015). 25950192

• Description:
  View product citations for LOX1 Antibody (OACD05298) on CiteAb

Target Info

• Gene Symbol: OLR1
• Gene Full Name: oxidized low density lipoprotein receptor 1
• Alias Symbols: bLOX-1;BLOX1;lectin-like oxidized LDL receptor 1;lectin-like oxLDL receptor 1;lectin-type oxidized LDL receptor 1;LOX-1;oxidised low density lipoprotein (lectin-like) receptor 1;oxidized low-density lipoprotein receptor 1;ox-LDL receptor 1.
• NCBI Gene Id: 281368
• Protein Name: Oxidized low-density lipoprotein receptor 1
• Description of Target: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
• Uniprot ID: P79391
• Protein Accession #: NP_776557.1
• Nucleotide Accession #: NM_174132
• Molecular Weight: 31 kDa