LAMP2 Antibody (OAEE00600)

Catalog No: OAEE00600

Size:100T

Product Info

• Predicted Species Reactivity: Human
• Product Format: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Clonality: Monoclonal
• Clone: H4B4
• Isotype: IgG1
• Host: Mouse
• Conjugation: FITC
• Application: Flow cytometry
• Reconstitution and Storage: 2°C to 8°C
• Immunogen: Human PBMC
• Purification: Purified by size-exclusion chromatography
• Concentration: 4 ul / test
• Specificity: The mouse monoclonal antibody H4B4 recognizes CD107b / LAMP-2, an extensively glycosylated 100-120 kDa widely expressed lysosome-associated protein.
  HLDA V.; WS Code P007
• Formulation: FITC
• Storage Buffer: The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
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Target Info

• Gene Symbol: LAMP2
• Gene Full Name: lysosomal associated membrane protein 2
• Alias Symbols: CD107 antigen-like family member B;CD107b;DND;LAMP-2;LAMPB;LGP110;LGP-96;lysosome-associated membrane glycoprotein 2.
• NCBI Gene Id: 3920
• Protein Name: Lysosome-associated membrane glycoprotein 2
• Description of Target: Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
• Uniprot ID: P13473
• Protein Accession #: NP_001116078.1; NP_002285.1; NP_054701.1
• Nucleotide Accession #: NM_001122606.1; NM_002294.2; NM_013995.2