KREMEN1 Recombinant Protein (OPCD04726)

Catalog No: OPCD04726

KREMEN1 Recombinant Protein (OPCD04726) using SDS-PAGE

KREMEN1 Recombinant Protein (OPCD04726) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Lys157-Gly390
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: KREMEN1
• Gene Full Name: kringle containing transmembrane protein 1
• Alias Symbols: dickkopf receptor;ECTD13;KREMEN;kremen protein 1;kringle domain-containing transmembrane protein 1;kringle-coding gene marking the eye and the nose;kringle-containing protein marking the eye and the nose;KRM1.
• NCBI Gene Id: 83999
• Protein Name: Kremen protein 1
• Description of Target: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.
• Uniprot ID: Q96MU8
• Protein Accession #: NP_001034659.2
• Nucleotide Accession #: NM_001039570.2
• Protein Size (# AA): Lys157~Gly390
• Molecular Weight: 29kDa