ITPR3 Antibody - N-terminal region (OABB01911)

Catalog No: OABB01911

Size:100UG

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Anti-ITPR3 Picoband antibody, OABB01911, Western blotting
All lanes: Anti ITPR3 (OABB01911) at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: SW620 Whole Cell Lysate at 40ug
Predicted bind size: 304KD
Observed bind size: 304KD

Anti-ITPR3 Picoband antibody, OABB01911, IHC(P)
IHC(P): Human Lung Cancer Tissue

Anti-ITPR3 Picoband antibody, OABB01911, IHC(P)
IHC(P): Mouse Intestine Tissue

Anti-ITPR3 Picoband antibody, OABB01911, IHC(P)
IHC(P): Rat Intestine Tissue

Product Info

• Tested Species Reactivity: Human, Mouse, Rat
• Predicted Species Reactivity: Chicken|Human|Mouse|Rat
• Product Format: Lyophilized. Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.
• Clonality: Polyclonal
• Clone: Polyclonal
• Isotype: Rabbit IgG
• Host: Rabbit
• Application: Immunohistochemistry|Western blot
• Additional Information: Notes: WB: The detection limit for ITPR3 is approximately 0.1ng/lane under reducing conditions.
  Tested Species: In-house tested species with positive results.
  By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.
  Other applications have not been tested.
  Optimal dilutions should be determined by end users.
  Background: ITPR3 encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.
• Reconstitution and Storage: 2°C to 8°C|-20°C
• Immunogen: Polypeptide
• Purification: Affinity Purified
• Peptide Sequence: Synthetic peptide located within the following region: QYWKAKQTKQDKEKIADVVLLQKLQH
• Concentration: 500 ug/ml
• Specificity: No cross reactivity with other proteins.
• Application Info: Western blot: 0.1-0.5 ug/ml: Human
  Immunohistochemistry (Paraffin-embedded Section): 0.5-1 ug/ml: Human, Mouse, Rat: By Heat
• Reference: 1. "Entrez Gene: inositol 1".
  2. Chaudhari N, Roper SD (August 2010)."The cell biology of taste". J. Cell Biol.190 (3): 285–96.
  3. Yamamoto-Hino M, Sugiyama T, Hikichi K et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors".Recept. Channels 2 (1): 9–22.
  
• Storage Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Description: Rabbit IgG polyclonal antibody for Inositol 1,4,5-trisphosphate receptor type 3(ITPR3) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

Target Info

• Gene Symbol: ITPR3
• Gene Full Name: inositol 1,4,5-trisphosphate receptor type 3
• Alias Symbols: inositol 1,4,5-triphosphate receptor, type 3;inositol 1,4,5-trisphosphate receptor type 3;insP3R3;IP3 receptor;IP3 receptor isoform 3;IP3R;IP3R3;Type 3 inositol 1,4,5-trisphosphate receptor;type 3 InsP3 receptor.
• NCBI Gene Id: 3710
• Protein Name: Inositol 1,4,5-trisphosphate receptor type 3
• Description of Target: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
• Uniprot ID: Q14573
• Molecular Weight: 304106 MW