HSD17B12 Recombinant Protein (OPCD03990)

Catalog No: OPCD03990

HSD17B12 Recombinant Protein (OPCD03990) using SDS-PAGE

HSD17B12 Recombinant Protein (OPCD03990) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Met1-Asn312
  Isoelectric Point: 9.0
  Subcellular Location: Endoplasmic reticulum lumen
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 80 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: Hsd17b12
• Gene Full Name: hydroxysteroid (17-beta) dehydrogenase 12
• Alias Symbols: 17-beta-HSD 12;17-beta-hydroxysteroid dehydrogenase 12;2610510O05Rik;3-ketoacyl-CoA reductase;AI172963;estradiol 17-beta-dehydrogenase 12;KAR;keratoadhesin;keratonectin;KIK;Kik1;KIK-I;steroid dehydrogenase;very-long-chain 3-oxoacyl-CoA reductase.
• NCBI Gene Id: 56348
• Protein Name: Very-long-chain 3-oxoacyl-CoA reductase
• Description of Target: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
• Uniprot ID: O70503
• Protein Accession #: NP_062631.1
• Nucleotide Accession #: NM_019657.4
• Protein Size (# AA): Met1~Asn312
• Molecular Weight: 64kDa