GRIA1 Antibody (OAAF01314)

Catalog No: OAAF01314 (Formerly GWB-ASC700)

Size:100 ug

Western blot analysis of extracts from COLO/Jurkat cells, using GluR1 Antibody. The lane on the right is treated with the synthesized peptide.

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GluR1 Antibody. The picture on the right is treated with the synthesized peptide.

Immunofluorescence analysis of HeLa cells, using GluR1 Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human GluR1.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: GluR1 (Ab-849) antibody detects endogenous levels of total GluR1 protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB: 1:500~1:3000; IHC: 1:50~1:100; IF: 1:100~1:500; ELISA: 1:40000
• Reference: Puckett C., Proc. Natl. Acad. Sci. U.S.A. 88:7557-7561(1991).
  Potier M.-C., DNA Seq. 2:211-218(1992).
  Sun W., Proc. Natl. Acad. Sci. U.S.A. 89:1443-1447(1992)

Target Info

• Gene Symbol: GRIA1
• Gene Full Name: glutamate ionotropic receptor AMPA type subunit 1
• Alias Symbols: AMPA 1;AMPA-selective glutamate receptor 1;GluA1;GLUH1;gluR-1;GLUR1;gluR-A;GLURA;gluR-K1;glutamate receptor 1;Glutamate receptor ionotropic, AMPA 1;glutamate receptor, ionotropic, AMPA 1;HBGR1.
• NCBI Gene Id: 2890
• Protein Name: Glutamate receptor 1
• Description of Target: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
• Uniprot ID: P42261
• Protein Accession #: NP_000818.2
• Molecular Weight: 101 kDa