GPER1 Antibody (OABF00668)

Catalog No: OABF00668

Size:100UL

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L1 human colon carcinoma, L2 mouse brain lysates probed (OABF00668) at 1:200 in 4C. Followed by conjugation to secondary antibody at 1:3000 90min in 37C. Predicted and observed band size: 42kDa

Formalin-fixed and paraffin embedded human gastric adenocarcinoma labeled with Rabbit Anti-GPR30 Polyclonal Antibody (OABF00668) at 1:300 followed by conjugation to the secondary antibody and DAB staining.

Formalin-fixed and paraffin embedded human rectal carcinoma tissue labeled with Rabbit Anti-GPR30 Polyclonal Antibody (OABF00668) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Product Info

• Tested Species Reactivity: Human, Mouse, Rat
• Predicted Species Reactivity: Bovine|Chicken|Horse|Human|Mouse|Rabbit|Rat
• Product Format: Liquid Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from human GPR30
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:300~1000
  ELISA: 1:500~1000
  FC: 1:20~100
  IHC-P: 1:200~400
  IHC-F: 1:100~500
  Fluorescent (IHC-P): 1:50~200
  Fluorescent (IHC-F): 1:50~200
  Fluorescent-ICC: 1:50~200

Target Info

• Gene Symbol: GPER1
• Gene Full Name: G protein-coupled estrogen receptor 1
• Alias Symbols: CEPR;chemoattractant receptor-like 2;chemokine receptor-like 2;CMKRL2;constitutively expressed peptide-like receptor;DRY12;FEG-1;flow-induced endothelial G-protein coupled receptor 1;G protein-coupled estrogen receptor 1;G protein-coupled receptor 30;GPCR-Br;GPER;GPR30;G-protein coupled estrogen receptor 1;G-protein coupled receptor 30;heptahelix receptor;IL8-related receptor DRY12;LERGU;LERGU2;LyGPR;lymphocyte-derived G-protein coupled receptor;membrane estrogen receptor;mER.
• NCBI Gene Id: 2852
• Protein Name: G-protein coupled estrogen receptor 1
• Description of Target: G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.
• Uniprot ID: Q99527
• Molecular Weight: 42 kDa