Goat Anti-Human Lambda Antibody - PE Conjugated (OASB02785)

Catalog No: OASB02785

Size:500UG

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Phosphate buffered saline containing 0.1% sodium azide and a stabilizer
• Clonality: Polyclonal
• Host: Goat
• Conjugation: R-PE
• Application: FC, FLISA
• Additional Information: Description: Pooled antisera from goats hyperimmunized with human lambda light chains; purified by affinity chromatography on human lambda light chains covalently linked to agarose; reacts with human lambda light chains; cross-adsorbed against human kappa light chains / mouse immunoglobulins and pooled sera for minimal reactivity
• Reconstitution and Storage: Store at 2-8C
• Immunogen: Human lambda light chains
• Concentration: 0.5 mg/mL
• Specificity: Lambda

Target Info

• Gene Symbol: IGL
• Gene Full Name: immunoglobulin lambda locus
• Alias Symbols: IGL@, IGLC6
• NCBI Gene Id: 3535
• Protein Name: ig lambda-6 chain C region
• Description of Target: Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species.