GALR2 Antibody - C-terminal region (ARP61395_P050)

Catalog No: ARP61395_P050

WB Suggested Anti-GALR2 Antibody
Titration: 1.0 ug/ml
Positive Control: A549 Whole CellGALR2 is supported by BioGPS gene expression data to be expressed in A549

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Horse
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Horse: 93%; Human: 100%
• Peptide Sequence: Synthetic peptide located within the following region: RGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPK
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-GALR2 (ARP61395_P050) antibody is Catalog # AAP61395 (Previous Catalog # AAPP47514)
• Sample Type Confirmation:

  GALR2 is supported by BioGPS gene expression data to be expressed in A549

Target Info

• Gene Symbol: GALR2
• Gene Full Name: Galanin receptor 2
• Alias Symbols: GAL2-R, GALNR2, GALR-2
• NCBI Gene Id: 8811
• Protein Name: Galanin receptor type 2
• Description of Target: Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.
• Uniprot ID: O43603
• Protein Accession #: NP_003848
• Nucleotide Accession #: NM_003857
• Protein Size (# AA): 387
• Molecular Weight: 43kDa
• Protein Interactions: GNAQ; GAL;