FGA Recombinant Protein (OPCD03171)

Catalog No: OPCD03171

FGA Recombinant Protein (OPCD03171) using SDS-PAGE

FGA Recombinant Protein (OPCD03171) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Bos taurus|Bovine
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Gly39-Pro615
  Isoelectric Point: 7.7
  Subcellular Location: Secreted.
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 120 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: FGA
• Gene Full Name: fibrinogen alpha chain
• Alias Symbols: A-alpha fibrinogen;fibrinogen A-alpha chain;fibrinogen alpha chain;fibrinogen, alpha polypeptide.
• NCBI Gene Id: 522039
• Protein Name: Fibrinogen alpha chain
• Description of Target: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
• Uniprot ID: P02672
• Protein Accession #: NP_001028798.1
• Nucleotide Accession #: NM_001033626.1
• Protein Size (# AA): Gly39~Pro615
• Molecular Weight: 67kDa