EPHA7 Antibody (OABF01776)

Catalog No: OABF01776

Size:100UL

Formalin-fixed and paraffin-embedded rat testis labeled with Anti--EphA7/Eph receptor A7 Polyclonal Antibody, Unconjugated (OABF01776) 1:200, overnight at 4C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37C.

Product Info

• Predicted Species Reactivity: Bovine|Chicken|Dog|Horse|Human|Mouse|Rabbit|Rat
• Product Format: Liquid. Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
• Additional Information: Subcellular location: Extracellular
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from human EphA7
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Specificity: There is a chance that this protein will cross-react with EphA4 based on a 73% non-sequential sequence similarity.
• Application Info: WB: 1:100 - 1000
  FC: 1:20 - 100
  IHC-P: 1:100 - 500
  Fluorescent-IHC: 1:50 - 200

Target Info

• Gene Symbol: EPHA7
• Gene Full Name: EPH receptor A7
• Alias Symbols: EHK3;EHK-3;EK11;EPH homology kinase 3;Eph homology kinase-3;EPH-like kinase 11;ephrin type-A receptor 7;HEK11;receptor protein-tyrosine kinase HEK11;tyrosine-protein kinase receptor EHK-3.
• NCBI Gene Id: 2045
• Protein Name: Ephrin type-A receptor 7
• Description of Target: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
• Uniprot ID: Q15375