E-64d (OOMC00016)

Catalog No: OOMC00016

Product Info

• Product Format: Powder
• Additional Information: CAS: 88321-09-9
  Molecular Formula: C17H30N2O5
  Chemical Name: 2S,3S-trans-(Ethoxycarbonyloxirane-2-carbonyl)-L-leucine-(3-methylbutyl)amide
  Primary Activity: Protease inhibitor: Cysteine proteases, Autophagy modulator
  COVID-19 Rationale: Blocks entry of SARS-CoV-2 into cells that cannot express TMPRSS2
• Reconstitution and Storage: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml). Store at -20C.
• Purity: > 98%
• Reference: 1) McGowan et al. (1989), Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64d; Biochem. Biophys. Res. Commun., 158 432 2) Wilcox and Mason (1992), Inhibition of cysteine proteinases in lysosomes and whole cells; Biochem. J., 285 495 3) Mizushima et al. (2010), Methods in mammalian autophagy research; Cell, 140 313

Target Info

• Molecular Weight: 342.43 g/mol