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Datasheets/Manuals | Printable datasheet for DNMT3A Antibody - Biotin Conjugated (OACA00373) (OACA00373) |
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Predicted Species Reactivity | Human |
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Product Format | Liquid |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Conjugation | Biotin |
Application | Enzyme-linked immunosorbent assay |
Reconstitution and Storage | -20°C or -80°C |
Immunogen | Recombinant Human DNA (cytosine-5)-methyltransferase 3A protein (680-902AA) |
Purification | Protein G Purified |
Purity | Caprylic Acid Ammonium Sulfate Precipitation purified |
Reference | [1] Cloning, expression and chromosome locations of the human DNMT3 gene family.'Xie S., Wang Z., Okano M., Nogami M., Li Y., He W.-W., Okumura K., Li E.Gene 236:87-95(1999) [2] A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.'Chen T., Ueda Y., Xie S., Li E.J. Biol. Chem. 277:38746-38754(2002) [3] Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases.'Kim G.-D., Ni J., Kelesoglu N., Roberts R.J., Pradhan S.EMBO J. 21:4183-4195(2002) |
Storage Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Gene Symbol | DNMT3A |
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Gene Full Name | DNA methyltransferase 3 alpha |
Alias Symbols | cysteine methyltransferase DNMT3A;DNA (cytosine-5-)-methyltransferase 3 alpha;DNA (cytosine-5)-methyltransferase 3A;DNA cytosine methyltransferase 3A2;DNA methyltransferase HsaIIIA;DNA MTase HsaIIIA;DNMT3A2;HESJAS;M.HsaIIIA;TBRS. |
NCBI Gene Id | 1788 |
Protein Name | DNA (cytosine-5)-methyltransferase 3A |
Description of Target | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. |
Uniprot ID | Q9Y6K1 |
Protein Accession # | NP_072046.2; NP_715640.2; NP_783328.1; NP_783329.1; XP_005264232.1; XP_005264234.1 |
Nucleotide Accession # | NM_022552.4; NM_153759.3; NM_175629.2; NM_175630.1; XM_005264175.3; XM_005264177.3 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "DNMT3A Antibody - Biotin Conjugated (OACA00373)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "DNMT3A Antibody - Biotin Conjugated (OACA00373)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
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What buffer format is "DNMT3A Antibody - Biotin Conjugated (OACA00373)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "DNMT3A Antibody - Biotin Conjugated (OACA00373)"?
This target may also be called "cysteine methyltransferase DNMT3A;DNA (cytosine-5-)-methyltransferase 3 alpha;DNA (cytosine-5)-methyltransferase 3A;DNA cytosine methyltransferase 3A2;DNA methyltransferase HsaIIIA;DNA MTase HsaIIIA;DNMT3A2;HESJAS;M.HsaIIIA;TBRS." in publications.
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What is the shipping cost for "DNMT3A Antibody - Biotin Conjugated (OACA00373)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "DNMT3A Antibody - Biotin Conjugated (OACA00373)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "DNMT3A Antibody - Biotin Conjugated (OACA00373)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "DNMT3A Antibody - Biotin Conjugated (OACA00373)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "DNMT3A"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "DNMT3A"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "DNMT3A"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "DNMT3A"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "DNMT3A"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "DNMT3A"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.