CYTH2 Antibody - C-terminal region (ARP70101_P050)

Catalog No: ARP70101_P050

Host: Rabbit
Target Name: CYTH2
Sample Tissue: Human MDA-MB-435S Whole Cell
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CYTH2
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100%
• Peptide Sequence: Synthetic peptide located within the following region: GRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPN
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-CYTH2 (ARP70101_P050) antibody is Catalog # AAP70101

Target Info

• Gene Symbol: CYTH2
• Alias Symbols: ARNO, CTS18, PSCD2, SEC7L, PSCD2L, CTS18.1, Sec7p-L, Sec7p-like, cytohesin-2
• NCBI Gene Id: 9266
• Protein Name: Cytohesin-2
• Description of Target: The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.
• Uniprot ID: Q99418
• Protein Accession #: NP_059431
• Nucleotide Accession #: NM_017457
• Protein Size (# AA): 400
• Molecular Weight: 46kDa
• Protein Interactions: CCDC120; UBC; ARF6; GNAQ; PNPLA2; DYT10; MAPK6; APC; IPCEF1; ATP6V0A2; CYTIP; ARFGAP1; TRIM23; ITGB2; PRKCG; PRKCB; PRKCA; CUX1; ARRB2; ARRB1; ARF1; ADORA2A; ARF3; SFN;