CSRP3 Antibody (OACA08010)

Catalog No: OACA08010

Immunohistochemistry of paraffin-embedded Human heart tissue at dilution 1:100

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue at dilution 1:100

Immunohistochemistry of paraffin-embedded Human heart tissue at dilution 1:100

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue at dilution 1:100

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Cysteine and glycine-rich protein 3 protein (1-194AA)
• Purification: Affinity Purified
• Preservative: 0.02% sodium azide
• Formulation: PBS with, 50% glycerol, pH7.3.

Target Info

• Gene Symbol: CSRP3
• Gene Full Name: cysteine and glycine rich protein 3
• Alias Symbols: cardiac LIM domain protein;Cardiac LIM protein;CLP;CMD1M;CMH12;CRP3;cysteine and glycine-rich protein 3;cysteine and glycine-rich protein 3 (cardiac LIM protein);Cysteine-rich protein 3;LIM domain only 4;LIM domain protein, cardiac;LMO4;MLP;Muscle LIM protein.
• NCBI Gene Id: 8048
• Protein Name: Cysteine and glycine-rich protein 3
• Description of Target: Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization (PubMed:19752190, PubMed:24934443). Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (PubMed:24934443). In vitro can inhibit PKC/PRKCA activity (PubMed:27353086). Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity).
• Uniprot ID: P50461
• Protein Accession #: NP_003467
• Nucleotide Accession #: NM_003476