CNOT2 Antibody (Phospho-Ser101) (OAAF00563)

Catalog No: OAAF00563 (Formerly GWB-ASC003)

Size:100 ug

Immunohistochemistry analysis of paraffin-embedded human brain, using CNOT2 (Phospho-Ser101) Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human CNOT2 around the phosphorylation site of Ser101.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: CNOT2 (Phospho-Ser101) antibody detects endogenous levels of CNOT2 only when phosphorylated at serine 101.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: IHC: 1:50~1:100; ELISA: 1:1000
• Reference: Albert T.K., Nucleic Acids Res. 28:809-817(2000).
  Zhang Q.-H., Genome Res. 10:1546-1560(2000).
  Ota T., Nat. Genet. 36:40-45(2004).

Target Info

• Gene Symbol: CNOT2
• Gene Full Name: CCR4-NOT transcription complex subunit 2
• Alias Symbols: CCR4-associated factor 2;CCR4-NOT transcription complex subunit 2;CDC36;HSPC131;IDNADFS;negative regulator of transcription 2;NOT2;NOT2H.
• NCBI Gene Id: 4848
• Protein Name: CCR4-NOT transcription complex subunit 2
• Description of Target: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.
• Uniprot ID: Q9NZN8
• Protein Accession #: NP_001186231.1
• Molecular Weight: 59 kDa