CCNE1 Antibody (OAAH00071)

Catalog No: OAAH00071

Size:100 ul

Western blot analysis of extracts from various cell lines: Lane 1-4: Hela, NIH/3T3, MCF-7, A431
Primary antibody: 1: 1000

Product Info

• Clonality: Polyclonal
• Isotype: Rabbit lgG
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: Store the product at -20C. Stable for one year from the date of shipment.
• Immunogen: Cyclin E1 polyclonal antibody is produced by immunizing rabbit with asynthetic peptide derived from human Cyclin E1
• Specificity: Cyclin E1 polyclonal antibody detects endogenous levels of total Cyclin E1 protein
• Source: Rabbit pAb
• Application Info: WB: 1: 1000-1: 2000
• Reference: 1. Greider, C. W., and Blackburn, E. H. (1985) Cell 43: 405-413.
  2. Ohtsubo, M., A. M. Theodoras, J. Schumacher, J. M. Roberts, and M.
  Pagano. (1995) Mol. Cell. Biol 15: 2612-2624.
  3. Greider, C.W. (1996) Annu. Rev. Biochem 65: 337-365.
  4. Porter et al. (1997) Nat. Med 3: 222

Target Info

• Gene Symbol: CCNE1
• Gene Full Name: G1/S-specific cyclin-E1
• Alias Symbols: CCNE, pCCNE1
• NCBI Gene Id: 898
• Protein Name: G1/S-specific cyclin-E1
• Description of Target: Cyclin E is a regulatory subunit of cdk-2 and controls G1/S transition during the mammalian cell cycle. Multiple isoforms of cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post-transcriptional regulation of cyclin E. In vitro analyses indicated that these truncated variant isoforms of cyclin E are able to phosphorylate histone H1. Alterations in cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
• Uniprot ID: P24864
• Protein Accession #: NP_001229.1; XP_006723520.1
• Nucleotide Accession #: NM_001238.2; XM_006723457.2
• Protein Size (# AA): 410
• Molecular Weight: 47 kDa