CCND2 Antibody (Phospho-Thr280) (OAAJ06410)

Catalog No: OAAJ06410

Size:100 uL

Western blot analysis of Cyclin D2 (Phospho-Thr280) expression in 293 cells

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid PBS (pH 7.4), 150mM NaCl, 0.02% sodium azide and 50% glycerol
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, ICC, IF, P-ELISA
  Subcellular Location: Nucleus
  Similarity: Belongs to the cyclin family. Cyclin D subfamily.
• Reconstitution and Storage: Store at -20°C. Stable for 12 months from date of receipt.
• Immunogen: A synthesized peptide derived from human Cyclin D2 (Phospho-Thr280)
• Purification: The Ab is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
• Concentration: 1 mg/mL
• Specificity: Cyclin D2 (Phospho-Thr280) Ab detects endogenous levels of total Cyclin D2 (Phospho-Thr280)
• Application Info: WB: 1:500~2000
  IF/ICC: 1:100~500
  P-ELISA: 1:20000~40000

Target Info

• Gene Symbol: CCND2
• Alias Symbols: MPPH3, KIAK0002
• NCBI Gene Id: 894
• Protein Name: G1/S-specific cyclin-D2
• Description of Target: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase.
• Uniprot ID: P30279
• Protein Accession #: NP_001750
• Nucleotide Accession #: NM_001759
• Molecular Weight: 33 kDa