CCL7 Protein (OPCB00004)

Catalog No: OPCB00004

Size:2ug

Migration Assay

Product Info

• Product Format: Lyophilized
• Application: CA
• Additional Information: Extinction Coefficient: 8730 M-1 cm-1
  Endotoxin Level: <0.01 EU per 1ug of the protein by the LAL method
• Reconstitution and Storage: Store for 12 months from date of receipt, at -20°C to -70°C as supplied. Spin tube prior to resuspending. Recommended at 100ug/mL in sterile water. Use immediately after reconstitution. Store for 1 month at -20°C to -70°C under sterile conditions after reconstitution.
• Purity: > 97% as determined by SDS-PAGE
• Biological Activity: EC50 = 0.44 nM determined by Migration Assay in cells expressing recombinant CCR2
• Protein Sequence: The protein sequence is: QPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEICADPTQKWVQDFMKHLDKKTQTPKL
• Source: E. coli
• Reference: 1. "Monocyte chemotactic protein-3"
  Menten P., Wuyts A., Van Damme J
  Eur. Cytokine Netw. 12:554-560 (2002)
  2. "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines".
  Opdenakker G., Froyen G., Fiten P., Proost P., Van Damme J.
  Biochem. Biophys. Res. Commun. 191: 535–42 (1993)
  3. "CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist."
  Blanpain C., Migeotte I., Lee B., Vakili J., Doranz B.J., Govaerts C., Vassart G., Doms R.W., Parmentier M.Blood 94:1899-1905 (1999)

Target Info

• Gene Symbol: CCL7
• Gene Full Name: chemokine (C-C motif) ligand 7
• Alias Symbols: FIC, MARC, MCP3, NC28, MCP-3, SCYA6, SCYA7
• NCBI Gene Id: 6354
• Description of Target: Monocyte chemotactic protein 3 (MCP3)(CCL7) is secreted by monocytes and certain tumer cell lines. It is a chemoattractant for monocytes and other leukocytes. MCP3 binds and signals through several cell surface receptors including CCR1, CCR2, CCR3, and appears to be an antagonist for CCR5.
• Uniprot ID: P80098
• Molecular Weight: 8.956 kDa