CAV1 Recombinant Protein (OPCD01923)

Catalog No: OPCD01923

CAV1 Recombinant Protein (OPCD01923) using SDS-PAGE

CAV1 Recombinant Protein (OPCD01923) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser2-Ser104
  Subcellular Location: Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; caveola; Membrane raf
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: Cav1
• Gene Full Name: caveolin 1, caveolae protein
• Alias Symbols: Cav;Cav-1;cave;caveolin, caveolae protein 1;caveolin, caveolae protein, 22 kDa;caveolin-1.
• NCBI Gene Id: 12389
• Protein Name: Caveolin-1
• Description of Target: Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (PubMed:10816572). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19546242).
• Uniprot ID: P49817
• Protein Accession #: NP_001229993.1
• Nucleotide Accession #: NM_001243064.1
• Protein Size (# AA): Ser2~Ser104
• Molecular Weight: 45kDa