Caspase-3 Antibody - N-terminal (OAPB01424)

Catalog No: OAPB01424

Size:100 ug

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid, 1 mg/mL provided in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: IHC-P
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: Caspase-3 antibody was raised against a 17 amino acid synthetic peptide near the center of human Caspase-3.
• Purification: Affinity chromatography purified via peptide column
• Concentration: 1 mg/mL

Target Info

• Gene Symbol: CASP3
• Gene Full Name: caspase 3
• Alias Symbols: CPP32, SCA-1, CPP32B
• NCBI Gene Id: 836
• Protein Name: caspase-3
• Description of Target: Caspase-3 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-3 is synthesized as an inactive proenzyme that undergoes proteolytic cleavage by caspases 8, 9 and 10 to produce 2 subunits, termed p20 and p11. These subunits dimerize to form the active enzyme. Caspase-3 proteolytically cleaves and activates other proteins such as caspases 6, 7 and 9.
• Uniprot ID: P42574
• Protein Accession #: NP_004337
• Nucleotide Accession #: NM_004346.3