CASP7 Antibody (OAPB00289)

Catalog No: OAPB00289 (Formerly GWB-5958CA)

Size:100UG

Western blot analysis of Caspase-7 in mouse skeletal muscle cell lysate with Caspase-7 antibody at (A) 0.5 and (B) 1 ug/mL.

Immunohistochemistry of caspase-7 in rat skeletal muscle tissue with caspase-7 antibody at 10 ug/mL.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. Caspase-7 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry-Paraffin|Western blot
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: Caspase-7 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: Caspase-7 antibody was raised against a 16 amino acid synthetic peptide from near the amino-terminus of human Caspase-7. The immunogen is located within amino acids 30 - 80 of Caspase-7.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-CASP7 (OAPB00289) antibody is Catalog # OEPB02382
• Application Info: Casp-7 antibody can be used for the detection of Caspase-7 by Western blot at 0.5 ug/ml. Depending on cell lines or tissues used, either full-length or other cleavage products may be observed. (Optimal dilution should be determined by user)
• Reference: Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.;Zhivotovsky B and Orrenius S. Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.;Wolf BB and Green DR. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. 1999; 274:20049-52.;Juan TSC, McNiece IK, Argento JM, et al. Identification and mapping of Casp7, a cysteine protease resembling CPP32b, Interleukin-1b converting enzyme, and CED-3. Genomics 1997; 40:86-93.

Target Info

• Gene Symbol: CASP7
• Gene Full Name: caspase 7
• Alias Symbols: apoptotic protease MCH-3;CASP-7;caspase 7, apoptosis-related cysteine peptidase;caspase 7, apoptosis-related cysteine protease;caspase-7;CMH-1;ICE-LAP3;ICE-like apoptotic protease 3;LICE2;MCH3.
• NCBI Gene Id: 840
• Protein Name: Caspase-7
• Description of Target: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
• Uniprot ID: P55210
• Protein Accession #: NP_001218.1; NP_001253985.1; NP_001253986.1; NP_001253987.1; NP_203124.1; NP_203125.1; NP_203126
• Nucleotide Accession #: NM_001227.4; NM_001267056.1; NM_001267057.1; NM_001267058.1; NM_033338.5; NM_033339.4