BMX Antibody (OAAF00942)

Catalog No: OAAF00942 (Formerly GWB-ASC354)

Size:100 ug

Western blot analysis of extracts from A549 cells, using ETK Antibody. The lane on the right is treated with the synthesized peptide.

Immunohistochemistry analysis of paraffin-embedded human thyroid gland tissue, using ETK Antibody. The picture on the right is treated with the synthesized peptide.

Immunofluorescence analysis of A549 cells, using ETK Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human ETK.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: ETK (Ab-566) antibody detects endogenous levels of total ETK protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB: 1:500~1:3000; IHC: 1:50~1:100; IF: 1:100~1:500; ELISA: 1:10000
• Reference: Sarah F. Hamm-Alvarez. Am J Physiol Cell Physiol, Jun 2001; 280: C1657 - C1668.
  Rozita Bagheri-Yarmand. J. Biol. Chem., Jul 2001; 276: 29403 - 29409.
  Yi-Mi Wu. J. Biol. Chem., May 2001; 276: 17672 - 17678.
  Bojie Dai. Cancer Res., Aug 2006;

Target Info

• Gene Symbol: BMX
• Gene Full Name: BMX non-receptor tyrosine kinase
• Alias Symbols: bone marrow tyrosine kinase gene in chromosome X protein;BTK-like on X chromosome;cytoplasmic tyrosine-protein kinase BMX;epithelial and endothelial tyrosine kinase;ETK;Etk/Bmx cytosolic tyrosine kinase;NTK38;NTK38 tyrosine kinase;PSCTK2;PSCTK3.
• NCBI Gene Id: 660
• Protein Name: Cytoplasmic tyrosine-protein kinase BMX
• Description of Target: Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.
• Uniprot ID: P51813
• Protein Accession #: NP_001712.1
• Molecular Weight: 78 kDa