ALDH1A3 Antibody - N-terminal region (OAAB04901)

Catalog No: OAAB04901

Size:400ul

Western blot analysis of anti-ALDH1A3 Antibody (N-term) in 293, Y79 cell line lysates (35ug/lane). This demonstrates the ALDH1A3 antibody detected the ALDH1A3 protein (arrow).

Formalin-fixed and paraffin-embedded human kidney tissue reacted with ALDH1A3 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: WB, IHC
  Function:  Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).
  Cellular Location: Cytoplasm (By similarity).
  Tissue Location: Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This ALDH1A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-51 amino acids from the N-terminal region of human ALDH1A3.
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Application Info: WB: 1:1000
  IHC-P: 1:10~50

Target Info

• Gene Symbol: ALDH1A3
• Alias Symbols: ALDH6, MCOP8, RALDH3, ALDH1A6
• NCBI Gene Id: 220
• Protein Name: Aldehyde dehydrogenase family 1 member A3
• Description of Target: Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme ALDH1A3 uses retinal as a substrate, either in a free or cellular retinol-binding protein form.
• Uniprot ID: P47895
• Protein Accession #: NP_000684.2
• Molecular Weight: 56108 Da