AHSG - Human Alpha-2-HS-GlycoProtein (OPPA01329)

Catalog No: OPPA01329 (Formerly GWB-182A7C)

Size:10UG

Product Info

• Product Format: Filtered (0.4 um) and lyophilized from 0.5 mg/ml in PBS pH 7.4. Physical appearance: Filtered White lyophilized (freeze-dried) powder.
• Host: Purified from the human plasma
• Application: ELISA, WB
• Additional Information: Solubility: It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile
  Product Introduction: Fetuin is a liver-produced negative acute phase protein composed of two subunits, the A and B chains.Fetuin homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR).Fetuin-A (alpha2-Heremans-Schmid glycoprotein; AHSG) is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase response.Sera from patients on long-term dialysis with low AHSG concentrations showed impaired ex-vivo capacity to inhibit CaxPO4 precipitation.Fetuin may influence the resolution of inflammation by modulating the phagocytosis of apoptotic cells by macrophages.ASHG blocks TGF-beta-dependent signaling in osteoblastic cells, and mice lacking ASHG display growth plate defects, increased bone formation with age, and enhanced cytokine-dependent osteogenesis.
• Reconstitution and Storage: Store the lyophilized protein at -20C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4C for a limited period of time; it does not show any change after two weeks at 4C. The lyophilized protein remains stable until the expiry date when stored at -20C.
• Purity: Greater than 95% as determined by SDS-PAGE.

Target Info

• Gene Symbol: Fetuin-A
• Alias Symbols: AHS, A2HS, HSGA, APMR1, FETUA
• NCBI Gene Id: 197
• Protein Name: Alpha-2-HS-glycoprotein
• Description of Target: Human Alpha-2-HS-Glycoprotein
• Uniprot ID: P02765
• Protein Accession #: NP_001613.2