RTN4 antibody - middle region (ARP46813_P050)

Catalog#: ARP46813_P050

• Size: 50ug

Human Muscle

• Description of Target: RTN4 belongs to the family of reticulons. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. RTN4 is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates.This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.
• Gene Symbol: RTN4
• Official Gene Full Name: Reticulon 4
• Alias Symbols: ASY; NI220/250; NOGO; NOGO-A; NOGOC; NSP; NSP-CL; Nbla00271; Nbla10545; Nogo-B; Nogo-C; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C
• Protein Accession#: NP_008939
• Nucleotide Accession#: NM_007008
• Swissprot Id: Q7L7Q5
• Host: Rabbit
• Clonality: Polyclonal
• Protein Size (# AA): 199
• Molecular Weight: 22kDa
• Application: WB
• Immunogen: The immunogen for anti-RTN4 antibody: synthetic peptide directed towards the middle region of human RTN4
• Product Format: Lyophilized powder
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Bovine: 100%; Dog: 100%; Guinea pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%
• Peptide Sequence: Synthetic peptide located within the following region: RAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAV
• Blocking Peptide: For anti-RTN4 antibody is Catalog # AAP46813 (Previous Catalog # AAPP27612)
• Key Reference: Hu,F. (2008) J. Neurosci. 28 (5), 1262-1269
• Reconstitution and Storage: Add 50 μl of distilled water. Final anti-RTN4 antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Product Protocols: RTN4 antibody tested with Human Fetal Muscle Tissue (ARP46813_P050)

Aviva Systems Biology is the original manufacturer of this RTN4 antibody (ARP46813_P050)

Click here to view the RTN4 antibody Western Blot Protocol

Product Datasheet Link: RTN4 antibody (ARP46813_P050)

WB Suggested Anti-RTN4 Antibody Titration: 0.2-1 ug/ml
Positive Control: Fetal Muscle

Western Blot image:


Description of Target: RTN4 belongs to the family of reticulons. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. RTN4 is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates.This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.

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Aviva Systems Biology’s RTN4 antibody (ARP46813_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

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