| Product Number |
ARP46813_P050 |
| Product Page |
www.avivasysbio.com/rtn4-antibody-middle-region-arp46813-p050.html |
| Name |
RTN4 Antibody - middle region (ARP46813_P050) |
| Protein Size (# AA) |
199 amino acids |
| Molecular Weight |
22kDa |
| NCBI Gene Id |
57142 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Reticulon 4 |
| Alias Symbols |
ASY, NSP, NOGO, RTN-X, NSP-CL, RTN4-A, RTN4-C, RTN4-B1, RTN4-B2, NI220/250, Nbla00271, Nbla10545 |
| Peptide Sequence |
Synthetic peptide located within the following region: RAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAV |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Hu,F. (2008) J. Neurosci. 28 (5), 1262-1269 |
| Description of Target |
RTN4 belongs to the family of reticulons. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. RTN4 is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates.This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. |
| Protein Interactions |
HUWE1; SYT16; ZFYVE21; RTN4; SNX15; ARL6IP1; SNX1; UBC; RPA3; RPA2; RPA1; vpu; BAIAP2; LAMA4; ATF2; CLN8; TMEM65; S100A16; EPPK1; SNX12; ACAA2; SLC9A3R2; TJP1; HNRNPM; ILF3; IGFBP7; DDB1; SLC25A10; CIRBP; TERF1; POT1; RPS27; NR4A1; HLA-DPB1; RTN3; RTN4IP1 |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-RTN4 (ARP46813_P050) antibody |
| Blocking Peptide |
For anti-RTN4 (ARP46813_P050) antibody is Catalog # AAP46813 (Previous Catalog # AAPP27612) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human RTN4 |
| Uniprot ID |
Q7L7Q5 |
| Protein Name |
Reticulon-4 |
| Protein Accession # |
NP_008939 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_007008 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
RTN4 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100% |
| Image 1 | Human Muscle
 | WB Suggested Anti-RTN4 Antibody Titration: 0.2-1 ug/ml
Positive Control: Human Muscle |
|
