CEP290 Antibody - middle region (OASG01479)

Catalog No: OASG01479

Size:100 uL

Western Blot using K562

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: LiquidPBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IF
• Additional Information: Cellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Nucleus Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasmic vesicle. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock . Found in the connecting cilium of photoreceptor cells, base of cilium in kidney intramedullary collecting duct cells . Localizes at the transition zone, a region between the basal body and the ciliary axoneme . Localization at the ciliary transition zone as well as at centriolar satellites is BBsome-dependent.
  Tissue Specificity: Ubiquitous. Expressed strongly in placenta and weakly in brain.
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the Internal region of human CEP290. Location: 740-820aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Specificity: CEP290 Polyclonal Antibody detects endogenous levels of CEP290 protein.
• Application Info: WB: 1:500~2000
  ELISA: 1:20000

Target Info

• Gene Symbol: CEP290
• Gene Full Name: centrosomal protein 290kDa
• Alias Symbols: CT87, MKS4, POC3, rd16, BBS14, JBTS5, LCA10, NPHP6, SLSN6, 3H11Ag
• NCBI Gene Id: 80184; 216274;
• Description of Target: CEP290 is a protein encoded by the CEP290 gene. CEP290 is localised to the cytoplasm. It is involved in regulation of PLK1 activity at G2/M transition, innate immune system and mitotic cell cycle. It is a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. It is involved in the early and late steps of cilia formation. CEP290 is ubiquitously expressed with stronger expression in the placenta. Mutations in the CEP290 gene may result in Joubert syndrome. STJ92224 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of CEP290 protein.
• Uniprot ID: O15078, Q6A078
• Molecular Weight: 290 kDa