WWP2 Recombinant Protein (OPCD00499)

Catalog No: OPCD00499

WWP2 Recombinant Protein (OPCD00499) using SDS-PAGE

WWP2 Recombinant Protein (OPCD00499) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: His601-Glu870
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: >95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: WWP2
• Gene Full Name: WW domain containing E3 ubiquitin protein ligase 2
• Alias Symbols: AIP2;atrophin-1 interacting protein 2;Atrophin-1-interacting protein 2;HECT-type E3 ubiquitin transferase WWP2;NEDD4-like E3 ubiquitin-protein ligase WWP2;WW domain-containing protein 2;WWp2-like.
• NCBI Gene Id: 11060
• Protein Name: NEDD4-like E3 ubiquitin-protein ligase WWP2
• Description of Target: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
• Uniprot ID: O00308
• Protein Accession #: NP_001257382.1
• Nucleotide Accession #: NM_001270453.1
• Protein Size (# AA): His601~Glu870
• Molecular Weight: 34kDa