NSMCE4A Antibody - C-terminal region (ARP70963_P050)

Catalog No: ARP70963_P050

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Host: Rabbit
Target Name: NSMCE4A
Sample Type: Fetal Lung lysates
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: NSMCE4A
Sample Tissue: Human Hela Whole Cell
Antibody Dilution: 0.5ug/ml

Host: Rabbit
Target: NSMCE4A
Positive control (+): HepG2 Cell Lysate (HG)
Negative control (-): A549 Cell Lysate (N03)
Antibody concentration: 0.5ug/ml

Sample Type:
HCT116
Primary Antibody Dilution:
4 ug/ml
Secondary Antibody:
Anti-rabbit Alexa 546
Secondary Antibody Dilution:
2 ug/ml
Gene Name:
NSMCE4A

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: IF, WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human NSMCE4A
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
• Peptide Sequence: Synthetic peptide located within the following region: PVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQTYFREDPDTPMSFF
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-NSMCE4A (ARP70963_P050) antibody is Catalog # AAP70963

Target Info

• Gene Symbol: NSMCE4A
• Alias Symbols: NS4EA, NSE4A, C10orf86
• NCBI Gene Id: 54780
• Protein Name: Non-structural maintenance of chromosomes element 4 homolog A
• Description of Target: NSMCE4A is a component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). It is involved in positive regulation of response to DNA damage stimulus.
• Uniprot ID: Q9NXX6
• Protein Accession #: NP_060085
• Nucleotide Accession #: NM_017615
• Protein Size (# AA): 385
• Molecular Weight: 44kDa
• Protein Interactions: UBC; HECW2; SRPK2; SRPK1; MAGED4B; NDNL2; MAGEC2; MAGEH1; MAGED2; NDN; MAGEB1; MAGEA1; NSMCE1; SMC6;