PLCG1 Antibody (OAAF00692)

Catalog No: OAAF00692 (Formerly GWB-ASC099)

Size:100 ug

Western blot analysis of extracts from HepG2, using PLCG1 Antibody. The lane on the right is treated with the synthesized peptide.

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using PLCG1 Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Monkey|Mouse|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human PLCG1.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: PLCG1 (Ab-771) antibody detects endogenous levels of total PLCG1 protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB: 1:500~1:3000; IHC: 1:50~1:100; ELISA: 1:10000
• Reference: Denis Tvorogov, J. Cell Sci., Feb 2005; 118: 601 - 610.
  Brenda J. Irvin, Mol. Cell. Biol., Dec 2000; 20: 9149 - 9161.
  Benoit Poulin, J. Biol. Chem., Feb 2000; 275: 6411.
  Ichiro Nakamura, J. Cell Biol., Jan 2001; 152: 361.

Target Info

• Gene Symbol: PLCG1
• Gene Full Name: phospholipase C gamma 1
• Alias Symbols: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1;inositoltrisphosphohydrolase;monophosphatidylinositol phosphodiesterase;NCKAP3;phosphatidylinositol phospholipase C;phosphoinositidase C;phosphoinositide phospholipase C;phosphoinositide phospholipase C-gamma-1;phospholipase C, gamma 1 (formerly subtype 148);phospholipase C-148;Phospholipase C-gamma-1;phospholipase C-II;PLC1;PLC148;PLC-148;PLCgamma1;PLC-gamma-1;PLC-II;triphosphoinositide phosphodiesterase.
• NCBI Gene Id: 5335
• Protein Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
• Description of Target: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
• Uniprot ID: P19174
• Protein Accession #: NP_002651.2
• Molecular Weight: 148 kDa