LYVE1 Antibody - C-terminal region (OAAB15548)

Catalog No: OAAB15548

Size:400ul

XLKD1 Antibody (C-term) (Cat. # OAAB15548) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the XLKD1 antibody detected the XLKD1 protein (arrow).

LYVE1 is strongly supported by BioGPS gene expression data to be expressed in HL60

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Product Info

• Predicted Species Reactivity: Human, Cow
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: IHC, WB
• Additional Information: Precautions: LYVE1 (XLKD1) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes
  Cellular Location: Membrane; Single-pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface
  Tissue Location: Mainly expressed in endothelial cells lining lymphatic vessels
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This LYVE1 (XLKD1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 amino acids from the C-terminal region of human LYVE1 (XLKD1).
• Predicted Homology Based on Immunogen Sequence: Cow; Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Sample Type Confirmation:

  LYVE1 is strongly supported by BioGPS gene expression data to be expressed in HL60

• Application Info: IHC-P: 1:50~100
  WB: 1:1000

Target Info

• Gene Symbol: LYVE1
• Alias Symbols: HAR, XLKD1, LYVE-1, CRSBP-1
• NCBI Gene Id: 10894
• Protein Name: Lymphatic vessel endothelial hyaluronic acid receptor 1
• Description of Target: Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: Q9Y5Y7
• Protein Accession #: NP_006682.2
• Molecular Weight: 35213 Da