DISC1 Recombinant Protein (OPCD02740)

Catalog No: OPCD02740

DISC1 Recombinant Protein (OPCD02740) using SDS-PAGE

DISC1 Recombinant Protein (OPCD02740) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser102-Cys261
  Subcellular Location: Cytoplasm
  Isoelectric Point: 6.1
  Phenomenon Explanation: The possible reasons that the actual band size differs from the predicted are as follows:
  1. Splice Variants: Alternative splicing may create different sized proteins from the same gene.
  2. Relative charge: The composition of amino acids may affect the charge of the protein.
  3. Post-translational modificaiton: Phosphorylation, glycosylation, methylation, etc.
  4. Post-translational cleavage: Many proteins are synthesized as pro-proteins, and then cleaved to give the active form.
  5. Polymerization of the target protein: Dimerization, multimerization etc.
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: DISC1
• Gene Full Name: DISC1 scaffold protein
• Alias Symbols: C1orf136;disrupted in schizophrenia 1 protein;SCZD9.
• NCBI Gene Id: 27185
• Protein Name: Disrupted in schizophrenia 1 protein
• Description of Target: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
• Uniprot ID: Q9NRI5
• Protein Accession #: NP_001012975.1
• Nucleotide Accession #: NM_001012957.1
• Protein Size (# AA): Ser102~Cys261
• Molecular Weight: 24kDa