CACNA1C Recombinant Protein (OPCD01816)

Catalog No: OPCD01816

CACNA1C Recombinant Protein (OPCD01816) using SDS-PAGE

CACNA1C Recombinant Protein (OPCD01816) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser1978-Leu2139
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: >95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Cacna1c
• Gene Full Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
• Alias Symbols: brain class C;calcium channel voltage-dependent alpha1c subunit;Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle;Cav1;Cav1.2;Cchl1;Cchl1a1;D930026N18Rik;MBC;MELC-CC;Mouse brain class C;neuronal voltage-gated calcium channel alpha 1C subunit;skeletal muscle-specific calcium channel;voltage-dependent L-type calcium channel subunit alpha-1C;voltage-gated calcium channel subunit alpha Cav1.2.
• NCBI Gene Id: 12288
• Protein Name: Voltage-dependent L-type calcium channel subunit alpha-1C
• Description of Target: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in opposite effects on the channel function.
• Uniprot ID: Q01815
• Protein Accession #: NP_001153005.1
• Nucleotide Accession #: NM_001159533.2
• Protein Size (# AA): Ser1978~Leu2139
• Molecular Weight: 25kDa