CDKN1B Antibody - C-terminal region (AVARP03039_P050)

• Product Number: AVARP03039_P050
• Name: CDKN1B Antibody - C-terminal region (AVARP03039_P050)
• Protein Size (# AA): 198 amino acids
• Molecular Weight: 22kDa
• NCBI Gene Id: 1027
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
• Alias Symbols: KIP1, MEN4, CDKN4, MEN1B, P27KIP1
• Peptide Sequence: Synthetic peptide located within the following region: EQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRR
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Azzato,E.M., (er) Breast Cancer Res. 10 (3), R47 (2008) In press
• Description of Target: CDKN1B is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. It binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Protein Interactions: CCND1; UBC; SGK1; PSMB1; CDK4; SKP2; CDK5; CDK3; CDK2; CDK1; SKP1; CKS1B; CCNE1; CCND3; CAMK1; YWHAQ; CCNA2; ABL1; TSC2; LYN; STMN1; RHOA; RPS6KA1; IRF1; KPNA6; CCNE2; CCNA1; VCP; SRC; MAPK10; MAPK8; CDC34; CDK6; RCHY1; COPS5; CUL1; HIST1H1A; CUL4A; JAK2;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-CDKN1B (AVARP03039_P050) antibody is Catalog # AAP30349 (Previous Catalog # AAPP00807)
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CDKN1B
• Uniprot ID: P46527
• Protein Name: Cyclin-dependent kinase inhibitor 1B
• Protein Accession #: NP_004055
• Purification: Affinity Purified
• Nucleotide Accession #: NM_004064
• Tested Species Reactivity: Human
• Gene Symbol: CDKN1B
• Predicted Species Reactivity: Human
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Human: 100%
• Image 1: Human 721_B
  
  WB Suggested Anti-CDKN1B Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:62500
  Positive Control: 721_B cell lysate