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Catalog No: AVARP03039_P050
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AVARP03039_P050
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Datasheets/ManualsPrintable datasheet for anti-CDKN1B (AVARP03039_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the C terminal region of human CDKN1B
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceHuman: 100%
Peptide SequenceSynthetic peptide located within the following region: EQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRR
Concentration0.5 mg/ml
Blocking PeptideFor anti-CDKN1B (AVARP03039_P050) antibody is Catalog # AAP30349 (Previous Catalog # AAPP00807)
ReferenceAzzato,E.M., (er) Breast Cancer Res. 10 (3), R47 (2008) In press
Gene SymbolCDKN1B
Gene Full NameCyclin-dependent kinase inhibitor 1B (p27, Kip1)
Alias SymbolsKIP1, MEN4, CDKN4, MEN1B, P27KIP1
NCBI Gene Id1027
Protein NameCyclin-dependent kinase inhibitor 1B
Description of TargetCDKN1B is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. It binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Uniprot IDP46527
Protein Accession #NP_004055
Nucleotide Accession #NM_004064
Protein Size (# AA)198
Molecular Weight22kDa
Protein InteractionsCCND1; UBC; SGK1; PSMB1; CDK4; SKP2; CDK5; CDK3; CDK2; CDK1; SKP1; CKS1B; CCNE1; CCND3; CAMK1; YWHAQ; CCNA2; ABL1; TSC2; LYN; STMN1; RHOA; RPS6KA1; IRF1; KPNA6; CCNE2; CCNA1; VCP; SRC; MAPK10; MAPK8; CDC34; CDK6; RCHY1; COPS5; CUL1; HIST1H1A; CUL4A; JAK2;
  1. What is the species homology for "CDKN1B Antibody - C-terminal region (AVARP03039_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "CDKN1B Antibody - C-terminal region (AVARP03039_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "CDKN1B Antibody - C-terminal region (AVARP03039_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "CDKN1B Antibody - C-terminal region (AVARP03039_P050)"?

    This target may also be called "KIP1, MEN4, CDKN4, MEN1B, P27KIP1" in publications.

  5. What is the shipping cost for "CDKN1B Antibody - C-terminal region (AVARP03039_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "CDKN1B Antibody - C-terminal region (AVARP03039_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "CDKN1B Antibody - C-terminal region (AVARP03039_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "22kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "CDKN1B Antibody - C-terminal region (AVARP03039_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "CDKN1B"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CDKN1B"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CDKN1B"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CDKN1B"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CDKN1B"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CDKN1B"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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