CDKN1B Antibody - C-terminal region (AVARP03039_P050)

Catalog No: AVARP03039_P050

WB Suggested Anti-CDKN1B Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: 721_B cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CDKN1B
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human: 100%
• Peptide Sequence: Synthetic peptide located within the following region: EQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRR
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-CDKN1B (AVARP03039_P050) antibody is Catalog # AAP30349 (Previous Catalog # AAPP00807)

Target Info

• Reference: Azzato,E.M., (er) Breast Cancer Res. 10 (3), R47 (2008) In press
• Gene Symbol: CDKN1B
• Gene Full Name: Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
• Alias Symbols: KIP1, MEN4, CDKN4, MEN1B, P27KIP1
• NCBI Gene Id: 1027
• Protein Name: Cyclin-dependent kinase inhibitor 1B
• Description of Target: CDKN1B is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. It binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: P46527
• Protein Accession #: NP_004055
• Nucleotide Accession #: NM_004064
• Protein Size (# AA): 198
• Molecular Weight: 22kDa
• Protein Interactions: CCND1; UBC; SGK1; PSMB1; CDK4; SKP2; CDK5; CDK3; CDK2; CDK1; SKP1; CKS1B; CCNE1; CCND3; CAMK1; YWHAQ; CCNA2; ABL1; TSC2; LYN; STMN1; RHOA; RPS6KA1; IRF1; KPNA6; CCNE2; CCNA1; VCP; SRC; MAPK10; MAPK8; CDC34; CDK6; RCHY1; COPS5; CUL1; HIST1H1A; CUL4A; JAK2;