Sku |
AAP30349 |
Old sku |
AAPP00807 |
Price |
$99.00 |
Name |
CDKN1B Peptide (AAP30349) |
Purchase info |
To purchase this peptide:
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|
Size |
100 ug |
Gene |
CDKN1B |
Alias symbols |
CDKN4, KIP1, MEN1B, MEN4, P27KIP1 |
Gene id |
1027 |
Description of target |
CDKN1B is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. It binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
Swissprot id |
P46527 |
Protein accession num |
NP_004055 |
Nucleotide accession num |
NM_004064 |
Protein size |
198 amino acids |
Molecular weight |
22kDa |
Application |
WB |
Partner proteins |
FOXO3,CCNA1,CCNA2,CCNA2,CCNA2,CCND1,CCNE1,CCNE1,CDK2,CDK2,CDK2,COPS5,E1A,E1A,KPNA2,SKP2,SKP2,STMN1,UBB,XPO1,ABL1,AKT1,ARHGDIA,CASP8,CCNA1,CCNA2,CCNB1,CCND1,CCND2,CCND3,CCNE2,CDK2,CDK3,CDK4,CDK5,CKS1B,COPS5,CUL4A,GRB2,KPNA3,KPNA5,LYN,MCM7,NUP50,SKP2,SRC,STMN1,TRAF2,TSC2,UBB,UCHL1,XPO1,YES1,YWHAB,YWHAE,YWHAG,YWHAH,YWHAQ,AKT1,ARHGDIA,CCNA1,CCNA2,CCND1,CCND2,CCND3,CCNE1,CDC34,CDK2,CDK4,CDK6,CKS1B,COPS5,CUL4A,GRB2,NUP50,SKP2,SPDYA,TRAF2,TSC1,TSC2,UBE2B,UBE2D2,UCHL1,XPO1,YWHAQ |
Quality control |
The peptide is characterized by mass spectroscopy |
Key reference |
Azzato,E.M., (er) Breast Cancer Res. 10 (3), R47 (2008) In press |
Description |
This is a synthetic peptide designed for use in combination with anti-CDKN1B antibody (Catalog #: AVARP03039_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
Product format |
Lyophilized powder |
Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
Protocol |
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Tips |
See our General FAQ page. |
Availability |
In Stock |
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