CDKN1B Peptide (AAP30349)

Data Sheet
 
Sku AAP30349
Old sku AAPP00807
Price $99.00
Name CDKN1B Peptide (AAP30349)
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Size 100 ug
Gene CDKN1B
Alias symbols CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Gene id 1027
Description of target CDKN1B is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. It binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot id P46527
Protein accession num NP_004055
Nucleotide accession num NM_004064
Protein size 198 amino acids
Molecular weight 22kDa
Application WB
Partner proteins FOXO3,CCNA1,CCNA2,CCNA2,CCNA2,CCND1,CCNE1,CCNE1,CDK2,CDK2,CDK2,COPS5,E1A,E1A,KPNA2,SKP2,SKP2,STMN1,UBB,XPO1,ABL1,AKT1,ARHGDIA,CASP8,CCNA1,CCNA2,CCNB1,CCND1,CCND2,CCND3,CCNE2,CDK2,CDK3,CDK4,CDK5,CKS1B,COPS5,CUL4A,GRB2,KPNA3,KPNA5,LYN,MCM7,NUP50,SKP2,SRC,STMN1,TRAF2,TSC2,UBB,UCHL1,XPO1,YES1,YWHAB,YWHAE,YWHAG,YWHAH,YWHAQ,AKT1,ARHGDIA,CCNA1,CCNA2,CCND1,CCND2,CCND3,CCNE1,CDC34,CDK2,CDK4,CDK6,CKS1B,COPS5,CUL4A,GRB2,NUP50,SKP2,SPDYA,TRAF2,TSC1,TSC2,UBE2B,UBE2D2,UCHL1,XPO1,YWHAQ
Quality control The peptide is characterized by mass spectroscopy
Key reference Azzato,E.M., (er) Breast Cancer Res. 10 (3), R47 (2008) In press
Description This is a synthetic peptide designed for use in combination with anti-CDKN1B antibody (Catalog #: AVARP03039_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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