UBQLN1 Antibody - middle region (ARP54958_P050)

• Product Number: ARP54958_P050
• Name: UBQLN1 Antibody - middle region (ARP54958_P050)
• Protein Size (# AA): 589 amino acids
• Molecular Weight: 62kDa
• NCBI Gene Id: 29979
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Ubiquilin 1
• Alias Symbols: DA41, DSK2, UBQN, XDRP1, PLIC-1
• Peptide Sequence: Synthetic peptide located within the following region: QFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTA
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Zhang,D., (2008) J. Mol. Biol. 377 (1), 162-180
• Description of Target: UBQLN1 is an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.
• Protein Interactions: MLLT6; MCM7; IL6ST; IGLC1; IGL; SLC29A2; HK2; GYPB; GRM2; GPX3; GABRD; FN1; FKBP2; FCGR2A; DEFA6; CTAG1B; CSTF2; COL10A1; COL1A2; CALU; IGLV2-14; FAM127B; CSTF2T; FAM127C; TMEM31; AGR3; ITPRIPL1; TRIM32; ACOT7; PLA2G16; SMR3B; AGR2; PSMD6; NUPL1; IST1; LI
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Additional Information: IHC Information: Human Lung, Respiratory Epithelium (formalin-fixed, paraffin-embedded) stained with UBQLN1 antibody ARP54958_P050 followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
• Blocking Peptide: For anti-UBQLN1 (ARP54958_P050) antibody is Catalog # AAP54958 (Previous Catalog # AAPP32119)
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human UBQLN1
• Uniprot ID: Q5T6J9
• Protein Name: Ubiquilin-1
• Protein Accession #: NP_038466
• Purification: Affinity Purified
• Nucleotide Accession #: NM_013438
• Tested Species Reactivity: Human
• Gene Symbol: UBQLN1
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish
• Application: IHC, WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 79%
• Image 1: human prostate
  
  Anti-UBQLN1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. UBQLN1 Antibody ARP54958_P050 concentration 5 ug/ml.
• Image 2: human brain, cortex
  
  Anti-UBQLN1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. UBQLN1 Antibody ARP54958_P050 concentration 5 ug/ml.
• Image 3: Human 293T
  
  WB Suggested Anti-UBQLN1 Antibody Titration: 1 ug/ml
  Positive Control: 293T cells lysate
• Image 4: Human Lung
  
  Immunohistochemistry with Human Lung, respiratory epethelium tissue at an antibody concentration of 5.0ug/ml using anti-UBQLN1 antibody (ARP54958_P050).