| Product Number |
ARP43609_P050 |
| Product Page |
www.avivasysbio.com/crebbp-antibody-n-terminal-region-arp43609-p050.html |
| Name |
CREBBP Antibody - N-terminal region (ARP43609_P050) |
| Protein Size (# AA) |
2404 amino acids |
| Molecular Weight |
261kDa |
| NCBI Gene Id |
1387 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
CREB binding protein |
| Description |
|
| Alias Symbols |
CBP, RSTS, KAT3A, MKHK1, RSTS1 |
| Peptide Sequence |
Synthetic peptide located within the following region: TPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNS |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Xia,Y., (2008) Biochem. Biophys. Res. Commun. 368 (2), 438-444 |
| Description of Target |
CREBBP is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREBBP has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. |
| Protein Interactions |
SUMO1; UBE2I; UBE2D1; TDG; RELA; CREBBP; KLF2; KLF4; WRN; PSME3; COPS2; UBC; BMI1; EID1; ATF4; DYRK1B; DYRK1A; ATF2; CREB1; CDK2; JUN; PPARG; IRF3; HNF4A; KLF1; vIRF-3; AR; vIRF-1; CNTN2; SMAD3; SMAD2; LDLR; STAT1; K8; MTDH; MEIS1; TLR2; EPAS1; MYBL1; LIG |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CREBBP (ARP43609_P050) antibody |
| Additional Information |
IHC Information: Colon, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)
IHC Information: Colon, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) |
| Blocking Peptide |
For anti-CREBBP (ARP43609_P050) antibody is Catalog # AAP43609 (Previous Catalog # AAPS13810) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CREBBP |
| Uniprot ID |
Q4LE28 |
| Protein Name |
CREBBP variant protein EMBL BAE06125.1 |
| Publications |
p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair. Cancers (Basel). 13 (2021). 33799418
p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair. Cancers (Basel). 13 (2021). 34884992 |
| Protein Accession # |
NP_001073315 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_001079846 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CREBBP |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
| Image 1 | Human Lung Tumor, Human Liver Tumor
 | Host: Rabbit
Target: CREBBP
Positive control (+): Human Lung Tumor (T-LU)
Negative control (-): Human Liver Tumor (T-LI)
Antibody concentration: 0.25ug/ml |
|
| Image 2 | Human Jurkat
 | WB Suggested Anti-CREBBP Antibody Titration: 1 ug/ml
Positive Control: Jurkat cell lysate |
|
| Image 3 | Human Breast
 | Anti-CREBBP antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. |
|
| Image 4 | Human Colon
 | Rabbit Anti-CREBBP Antibody
Catalog Number: arp43609
Paraffin Embedded Tissue: Human Colon
Antibody Concentration: 5 ug/ml |
|
