CREBBP Antibody - N-terminal region (ARP43609_P050)

Catalog No: ARP43609_P050

WB Suggested Anti-CREBBP Antibody Titration: 1 ug/ml
Positive Control: Jurkat cell lysate

Host: Rabbit
Target: CREBBP
Positive control (+): Human Lung Tumor (T-LU)
Negative control (-): Human Liver Tumor (T-LI)
Antibody concentration: 0.25ug/ml

Anti-CREBBP antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Rabbit Anti-CREBBP Antibody
Catalog Number: arp43609
Paraffin Embedded Tissue: Human Colon
Antibody Concentration: 5 ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: IHC, WB
• Additional Information: IHC Information: Colon, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)
  IHC Information: Colon, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CREBBP
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: TPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNS
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-CREBBP (ARP43609_P050) antibody is Catalog # AAP43609 (Previous Catalog # AAPS13810)
• Reference: Xia,Y., (2008) Biochem. Biophys. Res. Commun. 368 (2), 438-444
• Publications:

  p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair. Cancers (Basel). 13 (2021). 33799418

  p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair. Cancers (Basel). 13 (2021). 34884992

Target Info

• Gene Symbol: CREBBP
• Gene Full Name: CREB binding protein
• Alias Symbols: CBP, RSTS, KAT3A, MKHK1, RSTS1
• NCBI Gene Id: 1387
• Protein Name: CREBBP variant protein EMBL BAE06125.1
• Description of Target: CREBBP is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREBBP has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain.
• Uniprot ID: Q4LE28
• Protein Accession #: NP_001073315
• Nucleotide Accession #: NM_001079846
• Protein Size (# AA): 2404
• Molecular Weight: 261kDa
• Protein Interactions: SUMO1; UBE2I; UBE2D1; TDG; RELA; CREBBP; KLF2; KLF4; WRN; PSME3; COPS2; UBC; BMI1; EID1; ATF4; DYRK1B; DYRK1A; ATF2; CREB1; CDK2; JUN; PPARG; IRF3; HNF4A; KLF1; vIRF-3; AR; vIRF-1; CNTN2; SMAD3; SMAD2; LDLR; STAT1; K8; MTDH; MEIS1; TLR2; EPAS1; MYBL1; LIG