| Product Number |
ARP40586_P050 |
| Product Page |
www.avivasysbio.com/hnrnpdl-antibody-c-terminal-region-arp40586-p050.html |
| Name |
HNRNPDL Antibody - C-terminal region (ARP40586_P050) |
| Protein Size (# AA) |
420 amino acids |
| Molecular Weight |
46kDa |
| NCBI Gene Id |
9987 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
heterogeneous nuclear ribonucleoprotein D like |
| Description |
|
| Alias Symbols |
HNRNP, JKTBP, HNRPDL, JKTBP2, LGMD1G, LGMDD3, laAUF1 |
| Peptide Sequence |
Synthetic peptide located within the following region: YSGYGGYDYTGYNYGNYGYGQGYADYSGQQSTYGKASRGGGNHQNNYQPY |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
0 |
| Description of Target |
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. |
| Protein Interactions |
SPRTN; SUMO2; SUMO3; UBC; RPA3; RPA2; RPA1; ERG; EED; RNF2; rev; PARK2; FBXO6; TARDBP; HMGA1; ITGA4; IL7R; IFIT3; IFIT2; FN1; CSNK2A1; BARD1; EEF2; EEF1A1; DDX3X; ATP6V1B1; HNRNPA3; WIPF2; RMDN3; MRPS16; UBE2S; LSM14A; RPL36; U2AF2; HNRNPUL1; HNRNPA0; HNR |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-HNRNPDL (ARP40586_P050) antibody |
| Blocking Peptide |
For anti-HNRNPDL (ARP40586_P050) antibody is Catalog # AAP40586 (Previous Catalog # AAPP22762) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human HNRPDL |
| Uniprot ID |
O14979 |
| Protein Name |
heterogeneous nuclear ribonucleoprotein D-like |
| Publications |
Anderson, E. S. et al. The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B. RNA 18, 1041-9 (2012). 22456266
Li, X., Johansson, C., Glahder, J., Mossberg, A.-K. & Schwartz, S. Suppression of HPV-16 late L1 5â-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs. Nucleic Acids Res. 41, 10488-508 (2013). 24013563
The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual window of treatment success" in RA patients.". Arthritis Res Ther. 23, 239 (2021). 34521462 |
| Protein Accession # |
NP_005454 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_005463 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
HNRNPDL |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79% |
| Image 1 | Human MCF-7
 | WB Suggested Anti-HNRPDL Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: MCF7 cell lysate |
|
