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HNRNPDL Antibody - C-terminal region (ARP40586_P050)

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100 ul
$319.00
In Stock
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Conjugation Options

ARP40586_P050-FITC Conjugated

ARP40586_P050-HRP Conjugated

ARP40586_P050-Biotin Conjugated

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Gene Symbol:
HNRNPDL
NCBI Gene Id:
9987
Official Gene Full Name:
heterogeneous nuclear ribonucleoprotein D like
Protein Name:
heterogeneous nuclear ribonucleoprotein D-like
Swissprot Id:
O14979
Protein Accession #:
NP_005454
Nucleotide Accession #:
NM_005463
Alias Symbols:
HNRNP, JKTBP, HNRPDL, JKTBP2, LGMD1G, laAUF1
Description of Target:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD.
Protein Size (# AA):
420
Molecular Weight:
46kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express HNRNPDL.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express HNRNPDL.
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human HNRPDL
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%
Complete computational species homology data:
Anti-HNRPDL (ARP40586_P050)
Peptide Sequence:
Synthetic peptide located within the following region: YSGYGGYDYTGYNYGNYGYGQGYADYSGQQSTYGKASRGGGNHQNNYQPY
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
SPRTN; SUMO2; SUMO3; UBC; RPA3; RPA2; RPA1; ERG; EED; RNF2; rev; PARK2; FBXO6; TARDBP; HMGA1; ITGA4; IL7R; IFIT3; IFIT2; FN1; CSNK2A1; BARD1; EEF2; EEF1A1; DDX3X; ATP6V1B1; HNRNPA3; WIPF2; RMDN3; MRPS16; UBE2S; LSM14A; RPL36; U2AF2; HNRNPUL1; HNRNPA0; HNR
Blocking Peptide:
For anti-HNRNPDL (ARP40586_P050) antibody is Catalog # AAP40586 (Previous Catalog # AAPP22762)
Datasheets/Manuals:
Printable datasheet for anti-HNRNPDL (ARP40586_P050) antibody
Target Reference:
0
Publications:

Anderson, E. S. et al. The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B. RNA 18, 1041-9 (2012). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 22456266

Li, X., Johansson, C., Glahder, J., Mossberg, A.-K. & Schwartz, S. Suppression of HPV-16 late L1 5’-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs. Nucleic Acids Res. 41, 10488-508 (2013). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 24013563

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