XPO1 Antibody - C-terminal region (ARP40465_P050)

Data Sheet
 
Product Number ARP40465_P050
Product Page www.avivasysbio.com/xpo1-antibody-c-terminal-region-arp40465-p050.html
Name XPO1 Antibody - C-terminal region (ARP40465_P050)
Protein Size (# AA) 1071 amino acids
Molecular Weight 123 kDa
NCBI Gene Id 7514
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Exportin 1 (CRM1 homolog, yeast)
Alias Symbols emb, CRM1, exp1, CRM-1
Peptide Sequence Synthetic peptide located within the following region: NKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSH
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Cheong,J.K., (2008) J. Biol. Chem. 283 (17), 11661-11676
Description of Target XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. XPO1 also regulates NFAT and AP-1.The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Interactions ABL1; UBC; HUWE1; ELAVL1; KEAP1; SUMO2; SUMO3; USP16; STAU1; CDC37L1; RNF2; rev; TUBB; SCPEP1; CAMK1D; DCPS; HSPA1L; HNRNPK; GNAI3; EEF2; CAPN2; TWF2; FERMT2; UBA3; NAE1; STK24; YWHAH; YWHAE; VCL; TUFM; PCYT2; PPP5C; PPP1CA; EGFR; LOC366310; CLN5; CLN3; S
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Enhanced Validation
WBY
SPR
YCHAROS
Datasheets/Manuals Printable datasheet for anti-XPO1 (ARP40465_P050) antibody
Blocking Peptide For anti-XPO1 (ARP40465_P050) antibody is Catalog # AAP40465 (Previous Catalog # AAPP22233)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human XPO1
Uniprot ID O14980
Protein Name Exportin-1
Sample Type Confirmation

XPO1 is supported by BioGPS gene expression data to be expressed in HeLa, HepG2

Protein Accession # NP_003391
Purification Affinity Purified
Nucleotide Accession # NM_003400
Tested Species Reactivity Human
Gene Symbol XPO1
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Yeast, Zebrafish
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Yeast: 85%; Zebrafish: 93%
Image 1
Human HepG2
Host: Rabbit
Target Name: XPO1
Sample Type: HepG2
Antibody Dilution: 1.0ug/mlXPO1 is supported by BioGPS gene expression data to be expressed in HepG2
Image 2
Human Hela
Host: Rabbit
Target Name: XPO1
Sample Type: Hela
Antibody Dilution: 1.0ug/mlXPO1 is supported by BioGPS gene expression data to be expressed in HeLa
Image 3
Human Pineal Tissue
Rabbit Anti-XPO1 Antibody
Catalog Number: ARP40465_P050
Formalin Fixed Paraffin Embedded Tissue: Human Pineal Tissue
Observed Staining: Cytoplasmic in pinealocytes
Primary Antibody Concentration: 1:100
Other Working Concentrations: 1/600
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec
Image 4
Human Heart
WB Suggested Anti-XPO1 Antibody Titration: 0.2-1 ug/ml
Positive Control: Human heart
 

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