Product Number |
ARP40465_P050 |
Product Page |
www.avivasysbio.com/xpo1-antibody-c-terminal-region-arp40465-p050.html |
Name |
XPO1 Antibody - C-terminal region (ARP40465_P050) |
Protein Size (# AA) |
1071 amino acids |
Molecular Weight |
123 kDa |
NCBI Gene Id |
7514 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Exportin 1 (CRM1 homolog, yeast) |
Alias Symbols |
emb, CRM1, exp1, CRM-1 |
Peptide Sequence |
Synthetic peptide located within the following region: NKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSH |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Cheong,J.K., (2008) J. Biol. Chem. 283 (17), 11661-11676 |
Description of Target |
XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. XPO1 also regulates NFAT and AP-1.The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
Protein Interactions |
ABL1; UBC; HUWE1; ELAVL1; KEAP1; SUMO2; SUMO3; USP16; STAU1; CDC37L1; RNF2; rev; TUBB; SCPEP1; CAMK1D; DCPS; HSPA1L; HNRNPK; GNAI3; EEF2; CAPN2; TWF2; FERMT2; UBA3; NAE1; STK24; YWHAH; YWHAE; VCL; TUFM; PCYT2; PPP5C; PPP1CA; EGFR; LOC366310; CLN5; CLN3; S |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Enhanced Validation |
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Datasheets/Manuals |
Printable datasheet for anti-XPO1 (ARP40465_P050) antibody |
Blocking Peptide |
For anti-XPO1 (ARP40465_P050) antibody is Catalog # AAP40465 (Previous Catalog # AAPP22233) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human XPO1 |
Uniprot ID |
O14980 |
Protein Name |
Exportin-1 |
Sample Type Confirmation |
XPO1 is supported by BioGPS gene expression data to be expressed in HeLa, HepG2 |
Protein Accession # |
NP_003391 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_003400 |
Tested Species Reactivity |
Human |
Gene Symbol |
XPO1 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Yeast, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Yeast: 85%; Zebrafish: 93% |
Image 1 | Human HepG2
| Host: Rabbit Target Name: XPO1 Sample Type: HepG2 Antibody Dilution: 1.0ug/mlXPO1 is supported by BioGPS gene expression data to be expressed in HepG2 |
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Image 2 | Human Hela
| Host: Rabbit Target Name: XPO1 Sample Type: Hela Antibody Dilution: 1.0ug/mlXPO1 is supported by BioGPS gene expression data to be expressed in HeLa |
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Image 3 | Human Pineal Tissue
| Rabbit Anti-XPO1 Antibody Catalog Number: ARP40465_P050 Formalin Fixed Paraffin Embedded Tissue: Human Pineal Tissue Observed Staining: Cytoplasmic in pinealocytes Primary Antibody Concentration: 1:100 Other Working Concentrations: 1/600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec
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Image 4 | Human Heart
| WB Suggested Anti-XPO1 Antibody Titration: 0.2-1 ug/ml Positive Control: Human heart |
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