| Product Number |
OABF01171 |
| Product Page |
www.avivasysbio.com/fos-antibody-phospho-thr325-oabf01171.html |
| Name |
FOS Antibody (Phospho-Thr325) (OABF01171) |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| NCBI Gene Id |
2353 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1 ug/ul |
| Gene Full Name |
Fos proto-oncogene, AP-1 transcription factor subunit |
| Alias Symbols |
activator protein 1;AP-1;cellular oncogene c-fos;Cellular oncogene fos;C-FOS;FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS);FBJ murine osteosarcoma viral oncogene homolog;Fos proto-oncogene, AP-1 trancription factor subunit;G0/G1 switch regulatory protein 7;p55;proto-oncogene c-Fos. |
| Product Format |
Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. |
| Description of Target |
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. |
| Reconstitution and Storage |
-20°C |
| Datasheets/Manuals |
Printable datasheet for FOS Antibody (Phospho-Thr325) (OABF01171) |
| Additional Information |
Subcellular location: Cytoplasm, Nucleus |
| Additional Information |
Modification: Phosphorylation (Thr325) |
| Application Info |
WB: 1:100 - 1000
IHC-P: : 1:100 - 500 |
| Immunogen |
KLH conjugated synthetic phosphopeptide derived from human c-Fos around the phosphorylation site of Thr325 |
| Uniprot ID |
P01100 |
| Protein Name |
Proto-oncogene c-Fos |
| Purification |
Protein A Purified |
| Gene Symbol |
FOS |
| Predicted Species Reactivity |
Chicken|Dog|Human|Mouse|Porcine|Rat|Sheep |
| Application |
Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot |
| Image 1 | Human rectal carcinoma
 | Formalin-fixed and paraffin embedded human rectal carcinoma labeled with Anti-Phospho-c-Fos (Thr325) Polyclonal Antibody, Unconjugated (OABF01171) at 1:200 followed by conjugation to the secondary antibody and DAB staining. |
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