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FOS Antibody (Phospho-Thr325) (OABF01171)

100 ul
$389.00
In Stock
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Conjugation Options

OABF01171-FITC Conjugated

OABF01171-HRP Conjugated

OABF01171-Biotin Conjugated

Predicted Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Conjugation:
Unconjugated
Application:
WB, IHC-P
Additional Information:
Subcellular location: Cytoplasm, Nucleus
:::
Modification: Phosphorylation (Thr325)
Reconstitution and Storage:
Store at -20C for 12 months.
Gene Symbol:
FOS
Official Gene Full Name:
FBJ murine osteosarcoma viral oncogene homolog
NCBI Gene Id:
2353
Swissprot Id:
P01100
Alias Symbols:
p55, AP-1, C-FOS,
Replacement Item:
This antibody may replace item sc-166940, HPA018531
Description of Target:
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Purification:
Purified by Protein A.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express FOS.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express FOS.
Immunogen:
KLH conjugated synthetic phosphopeptide derived from human c-Fos around the phosphorylation site of Thr325
Concentration:
1ug/ul
Datasheets/Manuals:
Printable datasheet for OABF01171
Application Info:
WB: 1:100 - 1000
IHC-P: : 1:100 - 500

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